Oral phosphodiesterase-5 inhibitors and sperm functions
نویسندگان
چکیده
منابع مشابه
Evolution of Phosphodiesterase-5 Inhibitors.
Correspondence to: Du Geon Moon Department of Urology, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Korea. Tel: +82-2-2626-3201, Fax: +82-2-2626-1321, E-mail: [email protected] Copyright © 2015 Korean Society for Sexual Medicine and Andrology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://c...
متن کاملPulmonary responses to selective phosphodiesterase-5 and phosphodiesterase-3 inhibitors.
OBJECTIVE To compare the direct pulmonary vasodilating activity and specificity of phosphodiesterase-5 (zaprinast) and phosphodiesterase-3 (milrinone) inhibitors on the pulmonary vascular (PV) bed of the spontaneously breathing cat with an intact chest. DESIGN Prospective, randomized animal study. SETTING Laboratory of university hospital. SUBJECTS Experiments were performed in vivo in in...
متن کامل[5-phosphodiesterase inhibitors and cardiovascular risk].
important predictors of erectile dysfunction. Am J Epidemiol 1994;140:930—7. [7] Roumeguère Th, Wespes E, Carpentier Y, Hoffmann P, Schulman CC. Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 2003;44:355—9. [8] Ponholzer A, Temml C, Obermayr R, Wehrberger C, Madersbacher S. Is erectile dysfunction an indicator for increased ...
متن کاملExpert Opinion Phosphodiesterase-5 Inhibitors and Migraine
CASE A 45-year-old man has a 10-year history of migraine without aura occurring about once a week relieved by an oral triptan. When he sought treatment for erectile dysfunction from a urologist, the side effect of triggering migraine was brought up. Now the patient and the urologist want my opinion about whether the patient should try an oral phosphodiesterase-5 inhibitor (PDE-5) and, if so, do...
متن کاملEffects of phosphodiesterase-5 inhibitors on sperm parameters and fertilizing capacity.
The aim of this review study is to elucidate the effects that phosphodiesterase 5 (PDE5) inhibitors exert on spermatozoa motility, capacitation process and on their ability to fertilize the oocyte. Second messenger systems such as the cAMP/adenylate cyclase (AC) system and the cGMP/guanylate cyclase (GC) system appear to regulate sperm functions. Increased levels of intracytosolic cAMP result i...
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ژورنال
عنوان ژورنال: International Journal of Impotence Research
سال: 2008
ISSN: 0955-9930,1476-5489
DOI: 10.1038/ijir.2008.29